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Article

GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells

7 Sept 2005

Abstract excerpt

Gfi-1B (growth factor independence-1B) gene is an erythroid-specific transcription factor, whose expression plays an essential role in erythropoiesis. Our laboratory has previously defined the human Gfi-1B promoter region and shown that GATA-1 mediates erythroid-specific Gfi-1B transcription. By further investigating the regulation of the Gfi-1B promoter, here we report that (i) Gfi-1B transcription is negatively...

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PMID: 16177182
DOI: 10.1093/nar/gki838

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