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Article

Transcription factor Gfi1 restricts B cell-mediated autoimmunity.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2008

Rathinam Chozhavendan, Lassmann Hans, Mengel Michael, Klein Christoph

Abstract excerpt

The zinc finger transcription factor Gfi1 (growth factor-independent-1) has been involved in various cellular differentiation processes. Gfi1 acts as a transcriptional repressor and splicing control factor upon binding to cognate binding sites in regulatory elements of its target genes. In this study, we report that Gfi1-deficient mice develop autoimmunity. Gfi1-deficient peripheral B cells show a...

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Source

Identifiers

PMID: 18941212
DOI: 10.4049/jimmunol.181.9.6222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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