Article
Gfi1:green fluorescent protein knock-in mutant reveals differential expression and autoregulation of the growth factor independence 1 (Gfi1) gene during lymphocyte development.
The Journal of biological chemistry - 24 Sept 2004
Yücel Raif, Kosan Christian, Heyd Florian, Möröy Tarik
Abstract excerpt
The Gfi1 gene encodes a 55-kDa transcriptional repressor protein with important functions in T-cell development, in granulopoiesis, and in the regulation of the innate immune response. To follow expression of the Gfi1 gene during the differentiation of specific immune cells, we have generated a mouse mutant in which the Gfi1 coding region is replaced by the gene for the green fluorescent protein (GFP). We found...
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