Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formation

8 Oct 2015

Abstract excerpt

The DNA-binding zinc finger transcription factors Gfi1 and Gfi1b were discovered more than 20 years ago and are recognized today as major regulators of both early hematopoiesis and hematopoietic stem cells. Both proteins function as transcriptional repressors by recruiting histone-modifying enzymes to promoters and enhancers of target genes. The establishment of Gfi1 and Gfi1b reporter mice made it possible to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood disorders and treatments
Share to Erythrocyte Function and Pathophysiology
Share to Hematological disorders and diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26447191
DOI: 10.1182/blood-2015-06-655043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formationPMID 26447191Read ↗

Transcription Factor GFI1B in Health and DiseaseSemantic proximity Read ↗

Gfi-1 Oncoproteins in HematopoiesisSemantic proximity Read ↗

Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development.Semantic proximity Read ↗

Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesisSemantic proximity Read ↗

GFI1B mutation causes a bleeding disorder with abnormal platelet function.Semantic proximity Read ↗

Gfi1–cells and circuits: unraveling transcriptional networks of development and diseaseSemantic proximity Read ↗

Thrombocytopenia and CD34 expression is decoupled from α-granule deficiency with mutation of the first growth factor-independent 1B zinc finger.Semantic proximity Read ↗

Role of GFI1 in Epigenetic Regulation of MDS and AML Pathogenesis: Mechanisms and Therapeutic ImplicationsSemantic proximity Read ↗

The GFI1 Gene Family: Evolution, Structure, and Its Role in Immune ResponsesSemantic proximity Read ↗

A novel homozygous GFI1B variant in 2 sisters with thrombocytopenia and severe bleeding tendency.Semantic proximity Read ↗

Characterization of a genomic region 8 kb downstream of GFI1B associated with myeloproliferative neoplasms.Semantic proximity Read ↗

Gfi1 regulates miR-21 and miR-196b to control myelopoiesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.