Article
Suppressive function of androgen receptor in bone resorption.
Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2003
Kawano Hirotaka, Sato Takashi, Yamada Takashi, Matsumoto Takahiro, Sekine Keisuke, Watanabe Tomoyuki, Nakamura Takashi, Fukuda Toru, Yoshimura Kimihiro, Yoshizawa Tatsuya, Aihara Ken-Ichi, Yamamoto Yoko, Nakamichi Yuko, Metzger Daniel, Chambon Pierre, Nakamura Kozo, Kawaguchi Hiroshi, Kato Shigeaki
Abstract excerpt
As locally converted estrogen from testicular testosterone contributes to apparent androgen activity, the physiological significance of androgen receptor (AR) function in the beneficial effects of androgens on skeletal tissues has remained unclear. We show here that inactivation of AR in mice using a Cre-loxP system-mediated gene-targeting technique caused bone loss in males but not in females. Histomorphometric...
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