Article
Estrogen receptors in skeletal metabolism: lessons from genetically modified models of receptor function.
Critical reviews in eukaryotic gene expression - 1 Jan 2002
McCauley Laurie K, Tözüm Tolga F, Rosol Thomas J
Abstract excerpt
Estrogens have long been known to be important for skeletal homeostasis, but their precise mechanisms of action in bone are still unclear. Mice with targeted deletions of the estrogen receptors alpha (ERalpha) and beta (ERbeta) have been generated by two research groups and several studies performed characterizing the phenotype of ERalpha knockout (ERKOalpha), ERbeta knockout (ERKObeta), or double deletion of...
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