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Article

Osteoblast deletion of exon 3 of the androgen receptor gene results in trabecular bone loss in adult male mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 2007

Notini Amanda J, McManus Julie F, Moore Alison, Bouxsein Mary, Jimenez Mark, Chiu W S Maria, Glatt Vaida, Kream Barbara E, Handelsman David J, Morris Howard A, Zajac Jeffrey D, Davey Rachel A

Abstract excerpt

UNLABELLED: The mechanism of androgen action on bone was studied in male mice with the AR deleted in mature osteoblasts. These mice had decreased trabecular bone volume associated with a decrease in trabecular number, suggesting that androgens may act directly on osteoblasts to maintain trabecula...

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Source

Identifiers

PMID: 17147488
DOI: 10.1359/jbmr.061117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17147488-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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