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Article

Estrogen responsiveness of bone formation in vitro and altered bone phenotype in aged estrogen receptor-alpha-deficient male and female mice.

European journal of endocrinology - 1 Feb 2005

Parikka Vilhelmiina, Peng ZhiQi, Hentunen Teuvo, Risteli Juha, Elo Teresa, Väänänen H Kalervo, Härkönen Pirkko

Abstract excerpt

OBJECTIVE: Although the beneficial effects of estrogen on bone are well known, the roles of estrogen receptors (ERs) in mediating these effects are not fully understood. METHODS: To study the effects of long-term ER alpha deficiency, bone phenotype was studied in aged ER alpha knockout (ERKO) mice. In addition, ERKO osteoclasts and osteoblasts were cultured in vitro. DESIGN AND RESULTS: Histomorphometric analysis...

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Identifiers

PMID: 15745940
DOI: 10.1530/eje.1.01832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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