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Article

The impact of caspase-12 on susceptibility to candidemia.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Mar 2012

Rosentul D C, Plantinga T S, Scott W K, Alexander B D, van de Geer N M D, Perfect J R, Kullberg B J, Johnson M D, Netea M G

Abstract excerpt

Candida is one of the leading causes of sepsis, and an effective host immune response to Candida critically depends on the cytokines IL-1β and IL-18, which need caspase-1 cleavage to become bioactive. Caspase-12 has been suggested to inhibit caspase-1 activation and has been implicated as a susceptibility factor for bacterial sepsis. In populations of African descent, CASPASE-12 is either functional or...

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Identifiers

PMID: 21706251
DOI: 10.1007/s10096-011-1307-x
PMCID: PMC3274675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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