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Article

The anti-inflammatory CASPASE-12 gene does not influence SLE phenotype in African-Americans.

Immunology letters - 1 May 2016

Fuchs Trista, Kelly Jennifer A, Simon Emily, Sivils Kathy L, Hermel Evan

Abstract excerpt

In the vast majority of human populations, the gene encoding CASPASE-12 (CASP12) has a premature termination codon that precludes the production of protein. However, approximately 20% of persons of recent African descent have a single nucleotide polymorphism (#rs497116; A->G) that turns the stop codon into one encoding Arg. The subsequent functional allele is a risk factor for sepsis as it uniquely downregulates...

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Identifiers

PMID: 26973091
DOI: 10.1016/j.imlet.2016.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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