Article
Persistence of full-length caspase-12 and its relation to malaria in West and Central African populations.
European cytokine network - 1 Jun 2010
McCall Matthew B B, Ferwerda Bart, Hopman Joost, Ploemen Ivo, Maiga Boubacar, Daou Modibo, Dolo Amagana, Hermsen Cornelus C, Doumbo Ogobara K, Bedu-Addo George, van der Meer Jos W, Troye-Blomberg Marita, van der Ven André J A M, Schumann Ralf R, Sauerwein Robert W, Mockenhaupt Frank P, Netea Mihai G
Abstract excerpt
BACKGROUND: The full-length (L-) variant of caspase-12 is believed to predispose to sepsis. It has been replaced in the genome of most human populations by the (S-) variant, which leads to premature termination of translation. Strikingly, the L-allele is still widely prevalent in African populati...
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