Article
SGS1 is required for telomere elongation in the absence of telomerase.
Current biology : CB - 23 Jan 2001
Huang P, Pryde F E, Lester D, Maddison R L, Borts R H, Hickson I D, Louis E J
Abstract excerpt
In S. cerevisiae, mutations in genes that encode telomerase components, such as the genes EST1, EST2, EST3, and TLC1, result in the loss of telomerase activity in vivo. Two telomerase-independent mechanisms can overcome the resulting senescence. Type I survival is characterized by amplification of the subtelomeric Y' elements with a short telomere repeat tract at the terminus. Type II survivors arise through the...
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