Article
An mre11 mutation that promotes telomere recombination and an efficient bypass of senescence.
Genetics - 1 Jul 2010
Joseph Immanual S, Kumari Alpana, Bhattacharyya Mrinal K, Gao Honghai, Li Bibo, Lustig Arthur J
Abstract excerpt
Preventing the formation of dysfunctional telomeres is essential for genomic stability. In most organisms, the ribo-nucleoprotein reverse transcriptase telomerase is responsible for telomere GT-strand elongation. However, in telomerase-negative cells, low-frequency recombination mechanisms can avert lethality by elongating critically short telomeres. This study focuses on the involvement of the budding yeast...
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