Article
The Ser(+r83k) mutation is a second site mutation of SerD affecting the N-terminus of serrate.
Genesis (New York, N.Y. : 2000) - 1 May 2004
Trang Tung T, Tannous Vera, Gu Yi, Mosher Jessica, Fleming Robert J
Abstract excerpt
The Serrate gene encodes an essential ligand for Notch signaling used during development of the adult wing and other systems in Drosophila melanogaster. Animals heterozygous or homozygous for the Ser(D) allele of this gene display characteristic defects in wing margin formation. We have characterized a spontaneously arising intragenic suppressor of Ser(D) named Ser(+r83k). Homozygous double mutant Ser(+r83k),...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Calcium-Binding Proteins
- DNA Primers
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Immunohistochemistry
- Intercellular Signaling Peptides and Proteins
- Jagged-1 Protein
- Male
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Sequence Homology, Amino Acid
- Serine
- Serrate-Jagged Proteins