The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster.

doi:10.1101/gad.4.12a.2188

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Article

The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster.

Genes & development - 1 Dec 1990

Fleming R J, Scottgale T N, Diederich R J, Artavanis-Tsakonas S

Abstract excerpt

Mutations in the third chromosome gene Serrate are shown to display genetic interactions with specific alleles of the neurogenic locus Notch, which encodes a transmembrane protein with epidermal growth factor (EGF) homology. Embryonic lethal Serrate mutations exhibit epidermal and neuronal defects, which are reminiscent of those produced by mutations in the Drosophila EGF receptor homolog gene. We present the...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Blotting, Northern
Calcium-Binding Proteins
Cloning, Molecular
Drosophila Proteins
Drosophila melanogaster
Ectoderm
Epidermal Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

ErbB Receptors

Gene Expression Regulation

Genes

Intercellular Signaling Peptides and Proteins

Jagged-1 Protein

Membrane Proteins

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 2125287
DOI: 10.1101/gad.4.12a.2188

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2125287-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster.PMID 2125287Read ↗

The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs.Semantic proximity Read ↗

The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation.Semantic proximity Read ↗

Serrate2 is disrupted in the mouse limb-development mutant syndactylism.Semantic proximity Read ↗

Phenotypic and molecular characterization of SerD, a dominant allele of the Drosophila gene Serrate.Semantic proximity Read ↗

Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila.Semantic proximity Read ↗

Hox genes differentially regulate Serrate to generate segment-specific structures.Semantic proximity Read ↗

The intracellular domain of X-Serrate-1 is cleaved and suppresses primary neurogenesis in Xenopus laevis.Semantic proximity Read ↗

The Ser(+r83k) mutation is a second site mutation of SerD affecting the N-terminus of serrate.Semantic proximity Read ↗

Beaded of Goldschmidt, an antimorphic allele of Serrate, encodes a protein lacking transmembrane and intracellular domains.Semantic proximity Read ↗

Identifications of three novel alleles of Serrate in Drosophila.Semantic proximity Read ↗

dAP-2 and defective proventriculus regulate Serrate and Delta expression in the tarsus of Drosophila melanogaster.Semantic proximity Read ↗

Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila.Semantic proximity Read ↗

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