Article
Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor.
The Journal of biological chemistry - 8 Mar 2013
Whiteman Pat, de Madrid Beatriz Hernandez, Taylor Paul, Li Demin, Heslop Rebecca, Viticheep Nattnee, Tan Joyce Zi, Shimizu Hideyuki, Callaghan Juliana, Masiero Massimo, Li Ji Liang, Banham Alison H, Harris Adrian L, Lea Susan M, Redfield Christina, Baron Martin, Handford Penny A
Abstract excerpt
We have mapped a Jagged/Serrate-binding site to specific residues within the 12th EGF domain of human and Drosophila Notch. Two critical residues, involved in a hydrophobic interaction, provide a ligand-binding platform and are adjacent to a Fringe-sensitive residue that modulates Notch activity. Our data suggest that small variations within the binding site fine-tune ligand specificity, which may explain the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.