Article
A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands.
Science (New York, N.Y.) - 30 Nov 2012
Yamamoto Shinya, Charng Wu-Lin, Rana Nadia A, Kakuda Shinako, Jaiswal Manish, Bayat Vafa, Xiong Bo, Zhang Ke, Sandoval Hector, David Gabriela, Wang Hao, Haltiwanger Robert S, Bellen Hugo J
Abstract excerpt
Notch signaling affects many developmental and cellular processes and has been implicated in congenital disorders, stroke, and numerous cancers. The Notch receptor binds its ligands Delta and Serrate and is able to discriminate between them in different contexts. However, the specific domains in Notch responsible for this selectivity are poorly defined. Through genetic screens in Drosophila, we isolated a...
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