Article
The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation.
Development (Cambridge, England) - 1 Mar 1994
Speicher S A, Thomas U, Hinz U, Knust E
Abstract excerpt
The Drosophila gene Serrate encodes a transmembrane protein with 14 EGF-like repeats in its extracellular domain. Here we show that loss-of-function mutations in this gene lead to larval lethality. Homozygous mutant larvae fail to differentiate the anterior spiracles, exhibit poorly developed mouth-hooks and show a severe reduction in the size of the wing and haltere primordia, which is not due to cell death. The...
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