Article
The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation.
Development (Cambridge, England) - 1 Mar 1994
Speicher S A, Thomas U, Hinz U, Knust E
Abstract excerpt
The Drosophila gene Serrate encodes a transmembrane protein with 14 EGF-like repeats in its extracellular domain. Here we show that loss-of-function mutations in this gene lead to larval lethality. Homozygous mutant larvae fail to differentiate the anterior spiracles, exhibit poorly developed mou...
Topics
- Animals
- Calcium-Binding Proteins
- Cell Division
- Drosophila
- Drosophila Proteins
- Immunohistochemistry
- Insect Hormones
- Intercellular Signaling Peptides and Proteins
- Jagged-1 Protein
- Membrane Proteins
- Morphogenesis
- Mutation
- Phenotype
- Serrate-Jagged Proteins
- Wings, Animal