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Article

Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila.

Development (Cambridge, England) - 1 Sept 1997

Sun X, Artavanis-Tsakonas S

Abstract excerpt

We examined the function of secreted forms of the two known Drosophila Notch ligands, DELTA and SERRATE, by expressing them under various promoters in the Drosophila developing eye and wing. The phenotypes associated with the expression of secreted Delta (DlS) or secreted Serrate (SerS) forms mimic loss-of-function mutations in the Notch pathway. Both genetic interactions between DlS or SerS transgenics and...

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Identifiers

PMID: 9310338
DOI: 10.1242/dev.124.17.3439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila.PMID 9310338Read ↗

The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster.Semantic proximity Read ↗

A dominant-negative form of Serrate acts as a general antagonist of Notch activation.Semantic proximity Read ↗

The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs.Semantic proximity Read ↗

Phenotypic and molecular characterization of SerD, a dominant allele of the Drosophila gene Serrate.Semantic proximity Read ↗

Identifications of three novel alleles of Serrate in Drosophila.Semantic proximity Read ↗

Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.Semantic proximity Read ↗

The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation.Semantic proximity Read ↗

Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila.Semantic proximity Read ↗

Lobe and Serrate are required for cell survival during early eye development in Drosophila.Semantic proximity Read ↗

Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage.Semantic proximity Read ↗

Serrate2 is disrupted in the mouse limb-development mutant syndactylism.Semantic proximity Read ↗

The intracellular domain of X-Serrate-1 is cleaved and suppresses primary neurogenesis in Xenopus laevis.Semantic proximity Read ↗

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