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Article

The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs.

Development (Cambridge, England) - 1 Mar 1991

Thomas U, Speicher S A, Knust E

Abstract excerpt

We describe the molecular characterization of the Drosophila gene Serrate (Ser), which encodes an integral membrane protein. The extracellular domain contains two cysteine-rich regions, one of which is organized in a tandem array of 14 EGF-like repeats. Antibodies directed against part of the extracellular region confirm the localization of the protein in the membrane. In the wing imaginal discs, the protein is...

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Source

Identifiers

PMID: 1840519
DOI: 10.1242/dev.111.3.749

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs.PMID 1840519Read ↗

The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster.Semantic proximity Read ↗

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The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation.Semantic proximity Read ↗

The Ser(+r83k) mutation is a second site mutation of SerD affecting the N-terminus of serrate.Semantic proximity Read ↗

Identifications of three novel alleles of Serrate in Drosophila.Semantic proximity Read ↗

Serrate2 is disrupted in the mouse limb-development mutant syndactylism.Semantic proximity Read ↗

Beaded of Goldschmidt, an antimorphic allele of Serrate, encodes a protein lacking transmembrane and intracellular domains.Semantic proximity Read ↗

Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila.Semantic proximity Read ↗

Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila.Semantic proximity Read ↗

A dominant-negative form of Serrate acts as a general antagonist of Notch activation.Semantic proximity Read ↗

The intracellular domain of X-Serrate-1 is cleaved and suppresses primary neurogenesis in Xenopus laevis.Semantic proximity Read ↗

Hox genes differentially regulate Serrate to generate segment-specific structures.Semantic proximity Read ↗

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