Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Serrate2 is disrupted in the mouse limb-development mutant syndactylism.

Nature - 16 Oct 1997

Sidow A, Bulotsky M S, Kerrebrock A W, Bronson R T, Daly M J, Reeve M P, Hawkins T L, Birren B W, Jaenisch R, Lander E S

Abstract excerpt

The mouse syndactylism (sm) mutation impairs some of the earliest aspects of limb development and leads to subsequent abnormalities in digit formation. In sm homozygotes, the apical ectodermal ridge (AER) is hyperplastic by embryonic day 10.5, leading to abnormal dorsoventral thickening of the limb bud, subsequent merging of the skeletal condensations that give rise to cartilage and bone in the digits, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Carrier Proteins
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression

Share to Genetic Linkage

Share to Membrane Proteins

Source

Identifiers

PMID: 9338782
DOI: 10.1038/39587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Serrate2 is disrupted in the mouse limb-development mutant syndactylism.PMID 9338782Read ↗

The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster.Semantic proximity Read ↗

The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs.Semantic proximity Read ↗

The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation.Semantic proximity Read ↗

The Hemimelic extra toes mouse mutant: Historical perspective on unraveling mechanisms of dysmorphogenesis.Semantic proximity Read ↗

Phenotypic and molecular characterization of SerD, a dominant allele of the Drosophila gene Serrate.Semantic proximity Read ↗

Hox genes differentially regulate Serrate to generate segment-specific structures.Semantic proximity Read ↗

A novel member of the F-box/WD40 gene family, encoding dactylin, is disrupted in the mouse dactylaplasia mutant.Semantic proximity Read ↗

Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila.Semantic proximity Read ↗

Doubleridge, a mouse mutant with defective compaction of the apical ectodermal ridge and normal dorsal-ventral patterning of the limb.Semantic proximity Read ↗

Pathogenesis of split-hand/split-foot malformation.Semantic proximity Read ↗

The Ser(+r83k) mutation is a second site mutation of SerD affecting the N-terminus of serrate.Semantic proximity Read ↗

dAP-2 and defective proventriculus regulate Serrate and Delta expression in the tarsus of Drosophila melanogaster.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.