Serrate2 is disrupted in the mouse limb-development mutant syndactylism.

doi:10.1038/39587

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Article

Serrate2 is disrupted in the mouse limb-development mutant syndactylism.

Nature - 16 Oct 1997

Sidow A, Bulotsky M S, Kerrebrock A W, Bronson R T, Daly M J, Reeve M P, Hawkins T L, Birren B W, Jaenisch R, Lander E S

Abstract excerpt

The mouse syndactylism (sm) mutation impairs some of the earliest aspects of limb development and leads to subsequent abnormalities in digit formation. In sm homozygotes, the apical ectodermal ridge (AER) is hyperplastic by embryonic day 10.5, leading to abnormal dorsoventral thickening of the li...

Topics

Amino Acid Sequence
Animals
Carrier Proteins
Chromosome Mapping
Crosses, Genetic
Ectoderm
Exons
Extremities
Female
Gene Expression
Genetic Linkage
Glycine
Intracellular Signaling Peptides and Proteins
Introns
Male
Membrane Proteins
Mice
Mice, Inbred BALB C

Source

Open in PubMed

Identifiers

PMID: 9338782
DOI: 10.1038/39587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9338782-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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