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Article

Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia.

The Journal of clinical investigation - 1 May 2004

Talbot Konrad, Eidem Wess L, Tinsley Caroline L, Benson Matthew A, Thompson Edward W, Smith Rachel J, Hahn Chang-Gyu, Siegel Steven J, Trojanowski John Q, Gur Raquel E, Blake Derek J, Arnold Steven E

Abstract excerpt

Eleven studies now report significant associations between schizophrenia and certain haplotypes of single-nucleotide polymorphisms in the gene encoding dysbindin-1 at 6p22.3. Dysbindin-1 is best known as dystrobrevin-binding protein 1 (DTNBP1) and may thus be associated with the dystrophin glycoprotein complex found at certain postsynaptic sites in the brain. Contrary to expectations, however, we found that when...

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Identifiers

PMID: 15124027
DOI: 10.1172/JCI20425
PMCID: PMC398430

Genes

DTNBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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