Article
Single point mutation on the gene encoding dysbindin results in recognition deficits.
Genes, brain, and behavior - 1 Jun 2018
Chang E H, Fernando K, Yeung L W E, Barbari K, Chandon T-S S, Malhotra A K
Abstract excerpt
The dystrobrevin-binding protein 1 (DTNBP1) gene is a candidate risk factor for schizophrenia and has been associated with cognitive ability in both patient populations and healthy controls. DTNBP1 encodes dysbindin protein, which is localized to synaptic sites and is reduced in the prefrontal cortex and hippocampus of patients with schizophrenia, indicating a potential role in schizophrenia etiology. Most...
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