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Article

DTNBP1 (dysbindin) gene variants: in vivo evidence for effects on hippocampal glutamate status.

Current pharmaceutical biotechnology - 1 Jun 2012

Wirth C, Schubert F, Lautenschlager M, Brühl R, Klär A, Majic T, Lang U E, Ehrlich A, Winterer G, Sander T, Schouler-Ocak M, Gallinat J

Abstract excerpt

INTRODUCTION: In linkage and association studies the DTNBP1 gene has been identified as a major susceptibility gene for schizophrenia. Reduced expression of DTNBP1 was found in the hippocampus and prefrontal cortex in post mortem brains of schizophrenic patients. In vitro and animal models provide evidence that the DTNBP1 gene product dysbindin modulates the activity of the neurotransmitter glutamate in...

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Identifiers

PMID: 22283763
DOI: 10.2174/138920112800784952

Genes

DTNBP1

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Related research

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DTNBP1 (dysbindin) gene variants: in vivo evidence for effects on hippocampal glutamate status.PMID 22283763Read ↗

DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in schizophrenic patients--support for the glutamate hypothesis of schizophrenias.Semantic proximity Read ↗

The DTNBP1 (dysbindin-1) gene variant rs2619522 is associated with variation of hippocampal and prefrontal grey matter volumes in humans.Semantic proximity Read ↗

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Association between CACNA1C gene rs100737 polymorphism and glutamatergic neurometabolites in bipolar disorder.Semantic proximity Read ↗

Analysis of HapMap tag-SNPs in dysbindin (DTNBP1) reveals evidence of consistent association with schizophrenia.Semantic proximity Read ↗

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Association of schizophrenia with DTNBP1 but not with DAO, DAOA, NRG1 and RGS4 nor their genetic interaction.Semantic proximity Read ↗

Effect of DAOA genetic variation on white matter alteration in corpus callosum in patients with first-episode schizophrenia.Semantic proximity Read ↗

A polymorphism in the dysbindin gene (DTNBP1) associated with multiple psychiatric disorders including schizophrenia.Semantic proximity Read ↗

Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia?Semantic proximity Read ↗

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