Schizophrenia-associated gene dysbindin-1 and tardive dyskinesia.

doi:10.1002/ddr.21681

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Article

Schizophrenia-associated gene dysbindin-1 and tardive dyskinesia.

Drug development research - 1 Aug 2021

Maes Miriam S, Lu Justin Y, Tiwari Arun K, Freeman Natalie, de Luca Vincenzo, Müller Daniel J, Voineskos Aristotle N, Potkin Steven G, Lieberman Jeffrey A, Meltzer Herbert Y, Remington Gary, Kennedy James L, Zai Clement C

Abstract excerpt

Tardive dyskinesia (TD) is a potentially irreversible movement disorder observed following long-term antipsychotic exposure. Its cause is unknown; however, a genetic component has been supported by studies of affected families. Dysbindin-1, encoded by the dystrobrevin-binding protein 1 DTNBP1 gene, has been associated with schizophrenia and is potentially involved in dopamine neurotransmission through its...

Topics

Adult
Dysbindin
Female
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Male
Schizophrenia
Tardive Dyskinesia

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Open in PubMed

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PMID: 32394511
DOI: 10.1002/ddr.21681

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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