Article
Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 2011
Shao Lisha, Shuai Yichun, Wang Jie, Feng Shanxi, Lu Binyan, Li Zuo, Zhao Yukai, Wang Lianzhang, Zhong Yi
Abstract excerpt
The dysfunction of multiple neurotransmitter systems is a striking pathophysiological feature of many mental disorders, schizophrenia in particular, but delineating the underlying mechanisms has been challenging. Here we show that manipulation of a single schizophrenia susceptibility gene, dysbindin, is capable of regulating both glutamatergic and dopaminergic functions through two independent mechanisms,...
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