Article
Cytoplasmic nuclear transfer of the actin-capping protein tropomodulin.
The Journal of biological chemistry - 16 Jul 2004
Kong Kimi Y, Kedes Larry
Abstract excerpt
Tropomodulin (Tmod) is a cytoskeletal actin-capping protein that interacts with tropomyosin at the pointed end of actin filaments. E-Tmod is an isoform that expresses predominantly in cardiac cells and slow skeletal muscle fibers. We unexpectedly discovered significant levels of Tmod in nuclei and then defined peptide domains in Tmod responsible for nuclear import and export. These domains resemble, and function...
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