Article
A nemaline myopathy-linked mutation inhibits the actin-regulatory functions of tropomodulin and leiomodin.
Proceedings of the National Academy of Sciences of the United States of America - 21 Nov 2023
Schultz Lauren E, Colpan Mert, Smith Garry E, Mayfield Rachel M, Larrinaga Tania M, Kostyukova Alla S, Gregorio Carol C
Abstract excerpt
Actin is a highly expressed protein in eukaryotic cells and is essential for numerous cellular processes. In particular, efficient striated muscle contraction is dependent upon the precise regulation of actin-based thin filament structure and function. Alterations in the lengths of actin-thin filaments can lead to the development of myopathies. Leiomodins and tropomodulins are members of an actin-binding protein...
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