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Article

Loss of Tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy.

Disease models & mechanisms - 1 Dec 2014

Berger Joachim, Tarakci Hakan, Berger Silke, Li Mei, Hall Thomas E, Arner Anders, Currie Peter D

Abstract excerpt

Nemaline myopathy is an inherited muscle disease that is mainly diagnosed by the presence of nemaline rods in muscle biopsies. Of the nine genes associated with the disease, five encode components of striated muscle sarcomeres. In a genetic zebrafish screen, the mutant träge (trg) was isolated based on its reduction in muscle birefringence, indicating muscle damage. Myofibres in trg appeared disorganised and...

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Identifiers

PMID: 25288681
DOI: 10.1242/dmm.017376
PMCID: PMC4257009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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