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Article

Phosphatidylinositol 3-kinase signaling is involved in neurogenesis during Xenopus embryonic development.

The Journal of biological chemistry - 2 Jul 2004

Peng Ying, Jiang Bing-Hua, Yang Pai-Hao, Cao Zongxian, Shi Xianglin, Lin Marie C M, He Ming-Liang, Kung Hsiang-Fu

Abstract excerpt

Phosphatidylinositol 3-kinase (PI3K) has numerous cellular functions, including cell survival and proliferation. In this study, we demonstrated that the expression of the active form of PI3K induced dorsal differentiation and axis duplication and strongly induced the expression of neural markers. In contrast, the inhibition of PI3K activity by its dominant negative mutant induced the phenotype of losing posterior...

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Identifiers

PMID: 15123704
DOI: 10.1074/jbc.M402294200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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