Dual control of neurogenesis by PC3 through cell cycle inhibition and induction of Math1.

doi:10.1523/JNEUROSCI.3860-03.2004

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Article

Dual control of neurogenesis by PC3 through cell cycle inhibition and induction of Math1.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Mar 2004

Canzoniere Daniela, Farioli-Vecchioli Stefano, Conti Filippo, Ciotti Maria Teresa, Tata Ada Maria, Augusti-Tocco Gabriella, Mattei Elisabetta, Lakshmana Madepalli K, Krizhanovsky Valery, Reeves Steven A, Giovannoni Roberto, Castano Francesca, Servadio Antonio, Ben-Arie Nissim, Tirone Felice

Abstract excerpt

Growing evidence indicates that cell cycle arrest and neurogenesis are highly coordinated and interactive processes, governed by cell cycle genes and neural transcription factors. The gene PC3 (Tis21/BTG2) is expressed in the neuroblast throughout the neural tube and inhibits cell cycle progression at the G1 checkpoint by repressing cyclin D1 transcription. We generated inducible mouse models in which the...

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PMID: 15056715
DOI: 10.1523/JNEUROSCI.3860-03.2004
PMCID: PMC6730030

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BTG2

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