The RNA helicase DDX3 induces neural crest by promoting AKT activity

Abstract excerpt

Mutations in the RNA helicase DDX3 have emerged as a frequent cause of intellectual disability in humans. Because many patients carrying DDX3 mutations have additional defects in craniofacial structures and other tissues containing neural crest (NC)-derived cells, we hypothesized that DDX3 is also important for NC development. Using Xenopus tropicalis as a model, we show that DDX3 is required for normal NC induct...

Topics

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• Cerebellar Neoplasms
• DEAD-box RNA Helicases
• Disease Progression
• Intellectual Disability
• Medulloblastoma
• Mutation
• Neurodevelopmental Disorders
• Phenotype

Identifiers and source

Literature Corpus work

b01eb991-a6b6-5ef9-b247-e32c4f7e9609

DOI

10.1101/785428