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Article

PAK4–6 in cancer and neuronal development

1 Apr 2012

Abstract excerpt

PAKs 4, 5 and 6 are members of the group B family of p21-activated kinases. Among this group, PAK4 has been most extensively studied. While it has essential roles in embryonic development, in adults high levels of PAK4 are frequently associated with cancer. PAK4 is overexpressed in a variety of cancers, and the Pak4 gene is amplified in some cancers. PAK4 overexpression is sufficient to cause oncogenic...

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PMID: 23125951
DOI: 10.4161/cl.21171

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