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Article

Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling.

Proceedings of the National Academy of Sciences of the United States of America - 21 Mar 2006

Riobó Natalia A, Lu Ke, Ai Xingbin, Haines Gwendolyn M, Emerson Charles P

Abstract excerpt

Hedgehogs (Hhs) are key signaling regulators of stem cell maintenance and tissue patterning in embryos, and activating mutations in the pathway that increase Gli transcriptional activity are causal in a diversity of cancers. Here, we report that phosphoinositide 3-kinase (PI3-kinase)-dependent Akt activation is essential for Sonic Hedgehog (Shh) signaling in the specification of neuronal fates in chicken neural...

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PMID: 16537363
DOI: 10.1073/pnas.0504337103
PMCID: PMC1450201

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Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling.PMID 16537363Read ↗

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