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Article

Akt regulates basic helix-loop-helix transcription factor-coactivator complex formation and activity during neuronal differentiation.

Molecular and cellular biology - 1 Jul 2003

Vojtek Anne B, Taylor Jennifer, DeRuiter Stacy L, Yu Jenn-Yah, Figueroa Claudia, Kwok Roland P S, Turner David L

Abstract excerpt

Neural basic helix-loop-helix (bHLH) transcription factors regulate neurogenesis in vertebrates. Signaling by peptide growth factors also plays critical roles in regulating neuronal differentiation and survival. Many peptide growth factors activate phosphatidylinositol 3-kinase (PI3K) and subsequently the Akt kinases, raising the possibility that Akt may impact bHLH protein function during neurogenesis. Here we...

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Identifiers

PMID: 12808085
DOI: 10.1128/MCB.23.13.4417-4427.2003
PMCID: PMC164860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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