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Article

An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors.

The Journal of biological chemistry - 2 Jul 2004

Harrison Craig A, Gray Peter C, Fischer Wolfgang H, Donaldson Cindy, Choe Senyon, Vale Wylie

Abstract excerpt

Activins control many physiologic and pathophysiologic processes in multiple tissues and, like other TGF-beta superfamily members, signal via type II (ActRII/IIB) and type I (ALK4) receptor serine kinases. ActRII/IIB are promiscuous receptors known to bind at least a dozen TGF-beta superfamily ligands including activins, myostatin, several BMPs, and nodal. Here we utilize a new screening procedure to rapidly...

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Source

Identifiers

PMID: 15123686
DOI: 10.1074/jbc.M402782200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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