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Article

Identification of a binding site on the type II activin receptor for activin and inhibin.

The Journal of biological chemistry - 4 Feb 2000

Gray P C, Greenwald J, Blount A L, Kunitake K S, Donaldson C J, Choe S, Vale W

Abstract excerpt

Type II activin receptors (ActRII and ActRIIB) are single-transmembrane domain serine/threonine kinase receptors that bind activin to initiate the signaling and cellular responses triggered by this hormone. Inhibin also binds type II activin receptors and antagonizes many activin effects. Here we describe alanine scanning mutagenesis of the ActRII extracellular domain. We identify a cluster of three hydrophobic...

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Source

Identifiers

PMID: 10652306
DOI: 10.1074/jbc.275.5.3206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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