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Article

Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation

10 Apr 2013

Abstract excerpt

Constitutively activating mutations in receptor kinases recruit downstream effector pathways independently of upstream signaling, with consequences ranging from developmental syndromes to cancer. Classic fibrodysplasia ossificans progressiva (FOP) is a congenital syndrome resulting from highly conserved activating mutations of the glycine-serine-rich (GS) regulatory domain of ACVR1, encoding bone morphogenetic...

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PMID: 23572558
DOI: 10.1128/mcb.01595-12

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Constitutively Active ALK2 Receptor Mutants Require Type II Receptor CooperationPMID 23572558Read ↗

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