Article
Activation of signalling by the activin receptor complex.
Molecular and cellular biology - 1 Mar 1996
Attisano L, Wrana J L, Montalvo E, Massagué J
Abstract excerpt
Activin exerts its effects by simultaneously binding to two types of p rotein serine/threonine kinase receptors, each type existing in various isoforms. Using the ActR-IB and ActR-IIB receptor isoforms, we have investigated the mechanism of activin receptor activation. ActR-IIB are phosphoproteins with demonstrable affinity for each other. However, activin addition strongly promotes an interaction between these...
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