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Article

The crystal structure of the BMP-2:BMPR-IA complex and the generation of BMP-2 antagonists.

The Journal of bone and joint surgery. American volume - 1 Jan 2001

Nickel J, Dreyer M K, Kirsch T, Sebald W

Abstract excerpt

BACKGROUND: Bone morphogenetic proteins (BMPs) and growth and differentiation factors (GDFs) belong to the large transforming growth factor-beta (TGF-beta) superfamily of multifunctional cytokines. Signaling of the BMPs requires the binding of the BMP to the BMP cell surface receptors BMPR-IA, BMPR-IB, and BMPR-II. Similar to other cytokines, members of the TGF-beta superfamily exhibit stringent specificity in...

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Source

Identifiers

PMID: 11263668

Genes

BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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