Article

BMPR2 inhibits activin- and BMP-signaling via wild type ALK2

2017-11-22

Abstract excerpt

Activin A is a member of the TGF-β superfamily and activates the transcription factors SMAD2/3 through the ALK4 type 1 receptor. Activin A has also been shown to activate SMAD1/5/8 through mutated variants of the type 1 receptor ALK2. Interestingly, we here show that both activin A and activin B could activate SMAD1/5/8 through endogenous wild type ALK2 in multiple myeloma cells. Knockdown of the type 2 receptor B...

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Identifiers and source

Literature Corpus work: 19c257b3-7133-5490-8d8d-86efae920ec3
DOI: 10.1101/222406

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