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Article

An Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2

1 Apr 2014

Abstract excerpt

Recombinant bone morphogenetic protein 2 (rhBMP2) has been used clinically to treat bone fractures in human patients. However, the high doses of rhBMP2 required for a therapeutic response can cause undesirable side effects. Here, we demonstrate that a novel Activin A/BMP2 (AB2) chimera, AB204, promotes osteogenesis and bone healing much more potently and effectively than rhBMP2. Remarkably, 1 month of AB204...

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Identifiers

PMID: 24692083
DOI: 10.1002/jbmr.2238

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Related research

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An Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2PMID 24692083Read ↗

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