Article
Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop.
eLife - 9 Jun 2020
Aykul Senem, Corpina Richard A, Goebel Erich J, Cunanan Camille J, Dimitriou Alexandra, Kim Hyon Jong, Zhang Qian, Rafique Ashique, Leidich Raymond, Wang Xin, McClain Joyce, Jimenez Johanna, Nannuru Kalyan C, Rothman Nyanza J, Lees-Shepard John B, Martinez-Hackert Erik, Murphy Andrew J, Thompson Thomas B, Economides Aris N, Idone Vincent
Abstract excerpt
Activin A functions in BMP signaling in two ways: it either engages ACVR1B to activate Smad2/3 signaling or binds ACVR1 to form a non-signaling complex (NSC). Although the former property has been studied extensively, the roles of the NSC remain unexplored. The genetic disorder fibrodysplasia ossificans progressiva (FOP) provides a unique window into ACVR1/Activin A signaling because in that disease Activin can...
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