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Article

A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.

BMC structural biology - 12 Feb 2007

Weber Dionys, Kotzsch Alexander, Nickel Joachim, Harth Stefan, Seher Axel, Mueller Uwe, Sebald Walter, Mueller Thomas D

Abstract excerpt

BACKGROUND: Bone morphogenetic proteins (BMPs) are key regulators in the embryonic development and postnatal tissue homeostasis in all animals. Loss of function or dysregulation of BMPs results in severe diseases or even lethality. Like transforming growth factors beta (TGF-betas), activins, growth and differentiation factors (GDFs) and other members of the TGF-beta superfamily, BMPs signal by assembling two...

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Share to Activin Receptors, Type II
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17295905
DOI: 10.1186/1472-6807-7-6
PMCID: PMC1802081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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