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Article

Structural basis for a functional antagonist in the transforming growth factor beta superfamily.

The Journal of biological chemistry - 2 Dec 2005

Cook Robert W, Thompson Thomas B, Kurup Sudhi P, Jardetzky Theodore S, Woodruff Teresa K

Abstract excerpt

Within the transforming growth factor beta superfamily, the agonist-antagonist relationship between activin and inhibin is unique and critical to integrated reproductive function. Activin acts in the pituitary to stimulate follicle-stimulating hormone, and is antagonized by endocrine acting, gonadally derived inhibin. We have undertaken a mutational analysis of the activin betaA subunit to determine the precise...

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Source

Identifiers

PMID: 16186117
DOI: 10.1074/jbc.M504591200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural basis for a functional antagonist in the transforming growth factor beta superfamily.PMID 16186117Read ↗

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Activins, Myostatin and Related TGF-β Family Members as Novel Therapeutic Targets for Endocrine, Metabolic and Immune DisordersSemantic proximity Read ↗

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