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Article

Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition.

The Journal of biological chemistry - 1 Jul 2022

Chu Kit-Yee, Malik Anjali, Thamilselvan Vijayalakshmi, Martinez-Hackert Erik

Abstract excerpt

BMPR2 is a type II Transforming Growth Factor (TGF)-β family receptor that is fundamentally associated with pulmonary arterial hypertension (PAH) in humans. BMPR2 shares functional similarities with the type II activin receptors ACVR2A and ACVR2B, as it interacts with an overlapping group of TGF-β family growth factors (GFs). However, how BMPR2 recognizes GFs remains poorly understood. Here, we solved crystal...

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Share to Activin Receptors, Type II
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35643319
DOI: 10.1016/j.jbc.2022.102076
PMCID: PMC9234707

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