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SNP discrimination through proofreading and OFF-switch of exo+ polymerase.

Molecular biotechnology - 1 May 2004

Zhang Jia, Li Kai, Pardinas Jose R, Liao Duan F, Li Hong J, Zhang Xu

Abstract excerpt

Single nucleotide polymorphisms (SNPs) are useful physical markers for genetic studies as well as the cause of some genetic diseases. To develop more reliable SNP assays, we examined the underlying molecular mechanisms by which deoxyribonucleic acid (DNA) polymerases with 3' exonuclease activity maintain the high fidelity of DNA replication. In addition to mismatch removal by proofreading, we have discovered a...

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PMID: 15122048
DOI: 10.1385/MB:27:1:75

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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