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Article

Exo-proofreading, a versatile SNP scoring technology.

Genome research - 1 May 2003

Cahill Patrick, Bakis Michele, Hurley James, Kamath Veena, Nielsen William, Weymouth Dina, Dupuis Josee, Doucette-Stamm Lynn, Smith Douglas R

Abstract excerpt

We report the validation of a new assay for typing single nucleotide polymorphisms (SNPs) that takes advantage of the 3'-to-5' exonuclease proofreading activity of many DNA polymerases. The assay uses one or more primers labeled on the 3' nucleotide base, and can be implemented in a variety of formats including a one-step PCR reaction that allows SNP typing directly from genomic DNA samples. The detection of...

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Identifiers

PMID: 12695330
DOI: 10.1101/gr.939903
PMCID: PMC430895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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