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Exo+ proofreading polymerases mediate genetic analysis and its application in biomedical studies.

Acta pharmacologica Sinica - 1 Mar 2005

Liao Duan-fang, Chen Lin-ling, Peng Cui-ying, Zhang Jia, Li Kai

Abstract excerpt

Polymerases with a proofreading function in their internal 3' to 5' exonuclease possess high fidelity for DNA replication both in vivo and in vitro. The obstacle facing Exo+ polymerases for single nucleotide polymorphism (SNP) detection could be bypassed by using primer-3'-termini modification. This hypothesis has been well tested using three types of modified allele specific primers with: 3' labeling, 3' to 5'...

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Identifiers

PMID: 15715925
DOI: 10.1111/j.1745-7254.2005.00056.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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