Article
DNA pooling as a tool for large-scale association studies in complex traits.
Annals of medicine - 1 Jan 2004
Norton Nadine, Williams Nigel M, O'Donovan Michael C, Owen Michael J
Abstract excerpt
Pooled genotyping is a powerful and efficient tool for high throughput association analysis, both case-control and family-based. The use of pooling designs can significantly reduce the consumable and labour costs of a study. At the same time, since it is also extremely efficient with DNA resources, pooling can be an extremely effective method for conserving DNA. Here, we consider the main points in study design,...
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